The Patient-Centered Outcomes Research Institute (PCORI) is developing a new initiative to facilitate the uptake of evidence from PCORI-funded research directly within health systems. Through the Health Systems Implementation Initiative (HSII), health care delivery systems and provider-aligned health plans will have the opportunity to improve health care and health outcomes to support lasting change. PCORI has issued a Request for Information (RFI) to get input from health systems and provider-aligned health plans, and responses are due July 15. To share more about this initiative and opportunities to contribute to its design, PCORI is hosting a webinar on June 29.